科研项目: 1.国家自然科学基金面上项目:外源性细胞外囊泡IGF1R调节小胶质细胞-星形胶质细胞交互作用的机制研究,82171353,2022.01~2025.12,龙乾发,主持,55万; 2.国家自然科学基金面上项目:MSCs外泌体介导的microRNAs调节小胶质细胞活化的作用机制研究,81871084,2019.01~2020.12,龙乾发,主持,25万; 3.国家自然科学基金青年项目: Notch信号系统对骨髓间充质干细胞向GABA能神经元分化的调节作用及机制研究,31301216,2014.01~2016.12,龙乾发,主持,21万; 4.陕西省杰出青年基金项目:富集细胞外囊泡的生物脑膜构建,2023-JC-JQ-69,2023.01.01 ~ 2025.12.31,龙乾发,主持,50万; 5.陕西省重点研发计划-重点项目:间充质干细胞外泌体的神经保护研究,2018ZDXM-SF-046,2018.01~2020.12,龙乾发,主持,75万; 6.西安英才计划领军创新人才项目:间充质干细胞及其细胞外囊泡转化研究,XAYC210023,2022.01 ~ 2025.01,龙乾发,主持,75万; 7. 陕西省青年科技新星计划项目:Mash1修饰的骨髓间充质干细胞对癫痫的治疗作用研究,2014KJXX--29,2014.01 ~ 2016.12,龙乾发,主持,10万; 8.陕西省自然科学基础研究计划面上项目:骨髓间充质干细胞向GABA能神经元分化的调节机制研究,2015JM8476,2015.01 ~ 2016.12,龙乾发,主持,2万; 9.卫生健康适宜技术推广项目:CT适时引导下软通道穿刺治疗脑出血,陕卫办科教函(2021)101号,2021.01~2021.12,龙乾发,主持,5万; 10.陕西省卫生健康科研基金项目:外泌体生物支架对脑损伤术后创面的保护性研究,2018D001,2018.10~2020.10,龙乾发,主持,1.5万; 学术论文: 1.Ruijing Zhao, Lina Wang, Tian Wang, Panan Xi’an, Hongkang Wang, Qianfa Long*, Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury. Journal of Controlled Release, 2022, 345:214-230. IF 11.467 2.Han Wang, Yuqi Liu, Junchen Li, Tian Wang, Yue Hei, Huiming Li, Xue Wang, Lina Wang, Ruijing Zhao, Weiping Liu*, Qianfa Long*, Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP / PS1 mice, Cell Death Discovery 2021, 7:230. IF 7.109 3.Qiang Luo#, Panpan Xian#, Tian Wang#, Shengxi Wu, Tangna Sun, Wenting Wang, Bo Wang, Hao Yang, Yanping Yang, Han Wang, Weiping Liu, Qianfa Long*, Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage. Theranostics, 2021, 11(12):5986-6005. IF 11.600 4.Tian Wang# , Zhe Jian , Andrius Baskys , Junle Yang , Jianying Li , Hua Guo, Yue Hei, Panpan Xian, Zhongzheng He, Zhengyu Li, Namiao Li, Qianfa Long*. MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system. Biomaterials. 2020 , 257:120264. IF15.304 5.Que Bai, Kai Han, Kai Dong, Caiyun Zheng, Yanni Zhang, Qianfa Long*, Tingli Lu*, Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing, International Journal of Nanomedicine, 2020, 15: 9717-9743. IF 7.033 6.Panpan Xian# , Yue Hei# , Rui Wang, Tian Wang, Junle Yang, Jianying Li, Zhengli Di, Zhiqin Liu, Andrius Baskys, Weiping Liu, Shengxi Wu*, Qianfa Long*, Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice, Theranostics, 2019, 9(20): 5956-5975. IF 11.600 7.Qianfa Long#, Upadhya Dinesh#, Hattiangady Bharathi, Dong-Ki Kim, An Su Yeon, Bing Shuai, Darwin J. Prockop*, Ashok K.Shetty* , Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus, Proc Natl Acad Sci U S A, 2017, E3536–E3545, IF 12.779 8.Qianfa Long*#, Qiang Luo, Kai Wang, Adrian Bates, Ashok K. Shetty, Mash1 dependent Notch signaling pathway regulates GABA-ergicneuron-like differentiation from bone marrow-derived mesenchymal stem cells, Aging and Disease, 2017, 8(4): 1-13, IF 9.968 获 奖: 1.龙乾发(1/1);王忠诚中国神经外科医师年度奖(2022,青年医师奖),中国医师协会,王忠诚医学基金会,中国神经外科医师最高荣誉奖,2023.03.032.龙乾发(1/1);陕西省杰出青年科学基金,陕西省科学技术厅,2023.01.06 3.龙乾发(1/1);西安市高层次人才(国家级领军),中共西安市委,人才奖,2022.03.09 4.龙乾发 (1/1);陕西省中青年科技领军人才, 陕西省科学技术厅, 人才奖,2021.11.22 5.龙乾发 (1/1);西安英才计划-领军创新人才, 中共西安市委人才领导工作小组, 2021.12.14 6.龙乾发 (1/1);西安青年科技人才奖, 中共西安市委人才领导工作小组, 2020.09 7.龙乾发(1/9);西安市科技进步二等奖, 西安市人民政府, 2018.01.10 8.龙乾发 (1/1);陕西省青年科技新星, 中共陕西省委组织部、陕西省科学技术厅、陕西省教育厅、陕西省人力资源和社会保障厅, 2014.01 专 利: 1.Exosomes and uses thereof in diseases of the brain 2.一种定向释放功能的外泌体复合胶原生物支架及其制备方法和用途 3.一种外泌体靶向缓释微球生物支架及其制备方法和用途 |