科研项目（近五年）：
1.北京大学人民医院，横向课题，2024PHB161，足踝部常见疾病手术质量标准化评估系统的研发及临床应用研究，2024-01至2026-12，在研，主持
2.医疗器械临床试验，（2014）械001-GK，评价生物型接骨空心螺钉用于膝关节及踝关节等处骨折块的固定的安全性和有效性，2024-01至2026-01，在研，主持
3.西安交通大学，自由探索与创新项目，xzy012022130，IL-6介导的炎症反应在糖尿病夏科氏关节病骨关节破坏中的作用机制研究，2022-07至2024-07，在研，主持
4.中共西安市委组织部，西安英才计划菁英创新人才项目，XAYC210060，踝关节炎发病机制与阶梯化防治关键技术，2022-01至2023-12，在研，主持
5.陕西省科技厅，一般项目-社会发展领域，2021-SF025，柔韧性平足症的数字化评估与不同干预方式的疗效分析，2021-01至2022-12，结题， 主持
6.西安市卫健委，面上培育项目，2021ms07, Wnt/β-连锁蛋白通过RANKL/OPG通路参与Charcot关节病发病的分子机制研究，2022-01至2024-12，在研，主持
7.西安市科技局，科技计划项目，2019114613YX001SF03(12)，糖尿病夏科氏关节病（DCA）相关基因的筛选与验证，2019-12至2021-12，结题，主持
8.陕西省科技厅，基础研究计划面上项目，2018JM7112， 糖尿病夏科氏关节病的病理损伤机制研究，2018-01至2019-12，结题，主持
学术论文（近三年）：
1.Liang JQ, Zhang Y, Yue Y, Feng H, Liu PL, Liang XJ, Zhao HM*. Radiological characteristics and injury mechanism of Logsplitter injury: a descriptive and retrospective study. BMC Musculoskelet Disord, 2024, 25(1): 585.
2.Wang C, Wang Z, Zhao H*, Zhang M*. Radiologic and Clinical Outcomes of the Dovetailed Notch Scarf Osteotomy for Correcting the First Metatarsal Pronation in Moderate to Severe Hallux Valgus Deformity: A Comparative Study. Foot Ankle Int, 2024, 45(7):728-736.
3.Feng H, Yue Y, Zhang Y, Liang J, Liu L, Wang Q, Feng Q, Zhao H*. Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering. Int J Nanomedicine, 2024, 19: 1189-1204.
4.Wang X, Li R, Zhao H*. Enhancing angiogenesis: Innovative drug delivery systems to facilitate diabetic wound healing. Biomed Pharmacother, 2024, 170: 116035.
5.Wang X, Zhang Y, Wu Y, Wang C, Li S, Yuan Y, Lv X, Liu Y, Chen F, Chen S, Zhang F, Guo X, Ning Y*, Zhao H*. Integration of miRNA in exosomes and single-cell RNA-seq profiles in endemic osteoarthritis, Kashin-Beck disease. Biofactors, 2024, 50(4): 725-737.
6.Wu Y, Gong Y, Zhang Y, Li S, Wang C, Yuan Y, Lv X, Liu Y, Chen F, Chen S, Zhang F, Guo X, Wang X*, Ning Y*, Zhao H*. Comparative Analysis of Gut Microbiota from Rats Induced by Se Deficiency and T-2 Toxin. Nutrients, 2023, 15(24): 5027.
7.Yang X, Liu P, Zhang Y, Lu J, Zhao H*. Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy. Int J Nanomedicine. 2023 Nov 1;18:6213-6232.
8.Wang X, Xu L, Hu X, Zhao H*, Yin J*. Musculoskeletal Ultrasound for the Diagnosis of Plantar Fasciitis: An Accuracy and Diagnostic Yield Study. Int J Gen Med. 2023 Oct 25;16:4765-4771.
9.Ning Y, Zhang F, Li S, Wang C, Wu Y, Chen S, Liu Y, Chen F, Guo X, Wang X*, Zhao H*. Integrative analysis of miRNA in cartilage-derived extracellular vesicles and single-cell RNA-seq profiles in knee osteoarthritis. Arch Biochem Biophys. 2023 Oct 15;748:109785.
10.Liang J, Liu L, Feng H, Yue Y, Zhang Y, Wang Q, Zhao H*. Therapeutics of osteoarthritis and pharmacological mechanisms: A focus on RANK/RANKL signaling. Biomed Pharmacother. 2023 Nov;167:115646.
11.Liang JQ, Zhang Y, Liu L, Wen XD, Liu PL, Yang XQ, Liang XJ, Zhao HM*. Modified hindfoot alignment radiological evaluation and application in the assessment of flatfoot. BMC Musculoskeletal Disorders, 2023, 24: 683.
12.Liang J, Liu P, Yang X, Liu L, Zhang Y, Wang Q, Zhao H*. Biomaterial-based scaffolds in promotion of cartilage regeneration: Recent advances and emerging applications. J Orthop Translat, 2023, 41: 54-62.
13.Lu J, Zhang Y, Yang X, Zhao H*. Harnessing exosomes as cutting-edge drug delivery systems for revolutionary osteoarthritis therapy. Biomed Pharmacother. 2023 Sep; 165: 115135.
14.Zhang S, Sun C, Zhang J, Wang Z, Zhao H*, Zhang M. Changes in the subtalar joint alignment after supramalleolar osteotomy for varus ankle arthritis. Foot Ankle Surg. 2023 Aug;29(6):475-480.
15.Wang X, Wu Y, Liu Y, Chen F, Chen S, Zhang F, Li S, Wang C, Gong Y, Huang R, Hu M, Ning Y, Zhao H*, Guo X. Altered gut microbiome profile in patients with knee osteoarthritis. Front Microbiol. 2023 May 12;14:1153424.
16.Liu P, Diao J, Wang Q, Liu H, Zhang Y, Liang J, Zhang F, Liang X, Zhao H*. Cartilage Damage Pathological Characteristics of Diabetic Neuropathic Osteoarthropathy. Anal Cell Pathol (Amst). 2023 May 8; 2023: 7573165.
17.Xu J, Wang J, Zhao H*. The Prevalence of Kashin-Beck Disease in China: a Systematic Review and Meta-analysis. Biol Trace Elem Res. 2023 Jul;201(7): 3175-3184.
18.Liu L, Wang Q, Zhang Y, Liang J, Liu P, Zhao H*. Therapeutics of Charcot neuroarthropathy and pharmacological mechanisms: A bone metabolism perspective. Front Pharmacol. 2023 Apr 12;14:1160278.
19.Zhang Y, Liang J, Liu P, Wang Q, Liu L and Zhao H*. The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies. Front Endocrinol. 2022, 13: 1063815.
20.Setiwalidi K, Fu J, Hei H, Nuer S, Zhang F, Chen S, Liu Y, Chen F, Li S, Wang C, Wu Y, Gong Y, Hu M, Huang R, Liu J, Zhang T, Ning Y*, Zhao H*, Guo X and Wang X. Differential expression of cyclins CCNB1 and CCNG1 is involved in the chondrocyte damage of kashin-beck disease. Front Genet. 2022, 13: 1053685.
21.Ning Y, Zhang P, Zhang F, Chen S, Liu Y, Chen F, Wu Y, Li S, Wang C, Gong Y, Hu M, Huang R, Zhao H*, Guo X, Wang X, Yang L. Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis. Front Genet. 2022. 18, 13: 1064565.
22.Yang J, Zhang Y, Liang J, Yang X, Liu L, Zhao H*. Fibronectin-1 is a dominant mechanism for rheumatoid arthritis via the mediation of synovial fibroblasts activity. Front Cell Dev Biol, 2022, 10: 1010114.
23.Zhang Y, Wang Q, Liang J, Liu L, Liu P, Zhao H*. Serum proteomic analysis of differentially expressed proteins and pathways involved in the mechanism of endemic osteoarthritis. Mol Omics. 2022, 18(8):745-753.
24.Yang XQ, Zhang Y, Wang Q, Liang JQ, Liu L, Liang XJ, Zhao HM*. Supramalleolar Osteotomy vs Arthrodesis for the Treatment of Takakura 3B Ankle Osteoarthritis. Foot Ankle Int. 2022, 43(9): 1185-1193.
25.Yang XQ, Zhang Y, Jia JH, Wang Q, Liang JQ, Tang YD, Liang XJ, Zhao HM*. Closed reduction and posterior percutaneous internal fixation for simple displaced talar neck fracture: a retrospective comparative study. Int Orthop, 2022 Sep; 46(9): 2135-2143.
26.Kang X, Liu Y, Gong Y, Huang L, Liu H, Hu M, Huang R, Chen F, Chen S, Zhang F, Ning Y, Li C, Zhou R, Zhao H*, Wang X, Guo X. The Status of Selenium and Zinc in the Urine of Children From Endemic Areas of Kashin-Beck Disease Over Three Consecutive Years. Front Nutr, 2022 Apr 8; 9: 862639.
27.Zhang Y, Liang J, Wen X, Liu P, Lu J, Zhao H*. Triplane osteotomy combined with talar non-weight-bearing area autologous osteochondral transplantation for osteochondral lesions of the talus. BMC Musculoskeletal Disorders, 2022, 23: 79.
28.聂光华, 杨鑫权, 张言, 王欣文, 温晓东, 赵宏谋*. 经后外侧“安全区”行平行螺钉内固定治疗HawkinsⅠ-Ⅲ型距骨颈骨折疗效分析. 中国修复重建外科杂志, 2023, 37(11): 1347-1352.
29.岳洋, 冯慧, 刘培珑, 刘亮, 梁景棋, 梁晓军, 赵宏谋*. 足踝部糖尿病夏科神经性关节病的临床诊治进展. 中国修复重建外科杂志, 2023, 37(11): 1438-1443.
30.梁景棋, 杨鑫权, 岳洋, 冯慧, 刘亮, 张言, 刘培珑, 赵宏谋*. 踝上截骨术治疗内翻型踝关节炎的有效性与危险因素分析. 中国修复重建外科杂志, 2023, 37(7): 788-795.
31.张言, 梁景棋, 刘培珑, 温晓东, 梁晓军, 赵宏谋*. 内踝三平面截骨骨软骨移植治疗距骨软骨病. 中国矫形外科杂志, 2022, 30(15): 1426-1429.
32.石超, 常鑫, 郭睿, 梁景棋, 李毅, 梁晓军, 赵宏谋*.青少年柔韧性平足症的诊断与治疗进展. 中国骨与关节损伤杂志, 2022, 37(10): 1117-1120.
33.唐一丁, 张言, 王琼, 梁晓军, 赵宏谋*. 拇外翻患者第一跖骨旋转的相关研究进展. 中华解剖与临床杂志, 2022, 27(8): 591-595.
34.梁景棋, 张言, 温晓东, 刘培珑, 刘亮, 王琼, 梁晓军, 赵宏谋*. 三平面截骨保关节手术治疗跟骨关节内骨折畸形愈合的疗效分析. 中华创伤骨科杂志, 2022, 24(4) : 293-298.
获 奖：
1.2024：陕西省高等学校科学技术研究优秀成果一等奖（2/10）
2.2023：陕西省科技进步三等奖（20224576）（4/7）
3.2022：西安市委组织部“地方级领军人才（C类高增次人才）”
4.2022：西安市红会医院“优秀科技工作者”
5.2021：西安市红会医院“研究生教学先进个人”
6.2021：西安市“菁英创新人才”
7.2021：西安市红会医院“高层次人才”
8.2020：陕西省科技进步二等奖（2020-J-204466-2-R02）（2/9）
9.2020：第七届“西安市青年科技人才奖”
10.2020：西安市红会医院“中青年领军人才”
11.2020：西安医学院“优秀教师”
专 利：
1.赵宏谋，梁景棋，张言，刘培珑，王琼，刘亮，温晓东，鹿军，李毅，梁晓军. 足踝形态综合信息采集系统及方法[P]. 发明专利
2.赵宏谋，刘元刚，吴少辉. 一种踝关节后侧融合板[P]. 实用新型专利
3.赵宏谋，刘元刚，吴少辉. 一种踝上截骨锁定板[P]. 实用新型专利
4.王玲, 朱思尧, 赵宏谋, 张言, 梁景棋, 刘培珑, 李涤尘. 一种柔性矫形鞋垫及其制备方法. 发明专利 |
