科研项目：
1.陕西省重点研发计划一项（可视化技术在脊柱外科中的开发和应用研究，下拨20万，配套,20万）（编号：2023-YBSF-667）
2.西安市卫健委项目一项（GD2、HER2双重靶向新型CAR-T细胞对骨肉瘤杀伤作用的研究，下拨6万，配套6万）（编号：2022ms06）
3.肿瘤生物学国家重点实验室开放课题一项（分泌免疫促凋亡蛋白的新型CAR-T的建立及其对HER2阳性胃癌细胞的杀伤作用，5万）（编号：CBSKL2019KF11）
4.西安市英才计划领军创新人才一项（可视化数字脊柱外科技术的开发与临床应用，50万）（编号：XARC220102）
5.西安市红会医院中青年领军人才一项（单乐群-中青年领军人才，30万）（编号：202001）
6.西安市红会医院中青年领军人才一项（单乐群-中青年领军人才，100万）（编号：202301）
学术论文：
1.Zhang H, Zheng W, Chen X, Longqi Sa,Yi Huo，Lingling Zhang, Lequn Shan, Tao Wang.DNAJC1 facilitates glioblastoma progression by promoting extracellular matrix reorganization and macrophage infiltration. J Cancer Res Clin Oncol. 2024;150(6):315. Published 2024 Jun 22. (IF=2.7)
2.Zheng W, Zhang H, Huo Y, Zhang L, Sa L, Shan L, Wang T. The role of ST3GAL4 in glioma malignancy, macrophage infiltration, and prognostic outcomes. Heliyon. 2024 Apr 23;10(9):e29829.(IF=4.0）
3.Wang B, Sun Y, Zhang J, Meng H, Zhang H, Shan L. Ultrasound-guided versus fluoroscopy-guided lumbar selective nerve root block: a retrospective comparative study [published correction appears in Sci Rep. 2024 Apr 11;14(1):8479.(IF=3.8)
4.Sai Ma, Longqi Sa, Jitao Zhang , Kuo Jiang, Baoguo Mi,Lequn Shan.KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration.Genetics and Molecular Biology. Genet Mol Biol. 2023,25;46(3):e20230002. 2023（IF=2.1）
5.Huo Y, Zhang H, Sa L, Zheng W, He Y, Lyu H, Sun M, Zhang L, Shan L, Yang A, Wang T. M1 polarization enhances the antitumor activity of chimeric antigen receptor macrophages in solid tumors. J Transl Med.2023;21(1):225.(IF=8.448）
6.KuoJiang，QianfengZhang,YongFan,JiaLi,JitaoZhang,WentaoWang,JinzhuFan,YunshanGuo,ShichangLiu,DingjunHao,YongxiangWang,LeiWang,andLequn Shan.MYC inhibition reprograms tumor immune microenvironmentby recruiting T lymphocytes and activating the CD40/CD40Lsystem in osteosarcoma. Cell Death Discovery.2022,8(1):1-12.（IF=7.113)
7.Jinjian Gao,Sai Ma,Fan Yang,Xu Chen,Wei Wang,Jianping Zhang,Yufang Li,Tao Wang,Lequn Shan.miR_x001e_193b Exhibits Mutual Interaction With MYC, and Suppresses Growth and Metastasis of Osteosarcoma. ONCOLOGY REPORTS. (SCI IF=3.041)
8.Chao-Yuan Ge, Ding-Jun Hao, Le-Qun Shan. Rare Bony Diastematomyelia Associated with IntraspinalTeratoma. Word Neurosurgery. 2020,1(133): 185-187.(SCI IF=1.723)
9.Kuo Jiang, Jia Li, Jitao Zhang, Lei Wang, Qianfeng Zhang, JunliGe, YunshanGuo, Biao Wang,Yi Huang, Tuanmin Yang, DingjunHao, Lequn Shan.SDF-1/CXCR4 axis facilitates myeloid-derivedsuppressor cells accumulationin osteosarcoma microenvironment and blunts the response toanti-PD-1therapy.International Immunopharmacology.2019,75(2019)105818 (IF=3.361)
10.Zhang JP, Li N, Bai WZ, Qiu XC, Ma BA, Zhou Y, Fan QY, Shan L. Notch ligand Delta-like 1 promotes the metastasis of melanoma by enhancing tumor adhesion. Braz J Med Biol Res. 2014,47(4):299-306. (SCI IF=1.85).
11.Shan LQ,Skaggs DL, Lee C, Kissinger C,MyungKS.Intensive Care Unit Versus Hospital Floor: A Comparative Study of Postoperative Management of Adolescent Idiopathic Scoliosis Patients.J Bone Joint Surg Am.2013, 95(7):e401-5 (SCI IF=4.309)
12.Shan LQ,MaS,Qiu XC, Wang T, Yu SB, Ma BA, Zhou Y, Fan QY, Yang AG. A novel recombinant immuno-tBid with a furin site effectively suppresses the growth of HER2-positive osteosarcoma cells in vitro. Oncol Rep. 2011, 25(2):325-331 (SCI IF=1.835).
13.Ma S, Shan LQ, Xiao YH, Li F, Huang L, Shen L, Chen JH. The cytotoxicity of methacryloxylethylcetyl ammonium chloride, a cationic antibacterial monomer, is related to oxidative stress and the intrinsic mitochondrial apoptotic pathway.Braz J Med Biol Res. 2011, 44(11):1125-33. (SCI IF:1.1) (共同第一)
14.Shan LQ, Ma S, Qiu XC, Zhou Y, Zhang Y, Zheng LH, Ren PC, Wang YC, Fan QY, Ma BA. Hydroxysafflor Yellow A protects spinal cords from ischemia/reperfusion injury in rabbits. BMC Neurosci. 2010, 13;11:98 (SCI IF=3.042).
15.Shan LQ, Qiu XC, Xu YM, Ji ZG, Yang TT, Chen X, Ma BA, Zhou Y, Fan QY, Yang AG. scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis. Cancer BiolTher. 2008, 7(11):1720- 1725. (SCI IF=2.873)
16.陈佳,王孟飞,张吉涛,李政,郝定均,单乐群.显微镜与冷光源辅助经椎间孔椎间融合术治疗腰椎间盘突出症的对比分析[J].现代医学,2020,48(03):298-302.
17.张吉涛,陈佳,李政,郝定均,单乐群.超声骨刀在脊髓型颈椎病全椎板切除术中的应用[J].中国脊柱脊髓杂志,2018,28(03):234-238.
18.单乐群,马保安,周勇,张明华,范清宇.足底内侧皮瓣在足跟部皮肤恶性肿瘤手术缺损修复中的应用[J].临床骨科杂志,2011,14(03):281-283.
19.单乐群,马保安,周勇,张明华,张勇,郑联合,李军.腓肠肌肌皮瓣治疗胫骨创伤性慢性骨髓炎伴骨与软组织缺损[J].临床军医杂志,2011,39(02):298-300.
20.单乐群,李存孝,马保安,袁军,马国治.高原地震骨科创伤的特点及救治[J].临床军医杂志,2011,39(01):140-141.
21.单乐群,马保安,周勇,张明华,张勇,郑联合,李军.远端蒂皮神经营养逆行皮瓣修复足踝部软组织缺损[J].中华实用诊断与治疗杂志,2010,24(12):1197-1199.
22.单乐群,马保安,张勇,郑联合,李军,孙嗣国,王育才.腓肠神经营养血管远端蒂皮瓣治疗足踝部软组织缺损[J].西北国防医学杂志,2010,31(03):164-166.
23.单乐群,马保安,周勇,张勇,郑联合,王育才,孙嗣国,范清宇.地震后送骨科伤员开放创面的治疗分析[J].中国现代手术学杂志,2010,14(03):196-198.
24.单乐群,马保安,张勇,郑联合,李军.肱骨髁间骨折两种入路的疗效比较[J].临床军医杂志,2010,38(02):203-205.
25.单乐群,马保安,张勇,郑联合,李军,王育才,李钊,孙嗣国,范清宇.内踝上逆行岛状皮瓣修复足踝部皮肤软组织缺损[J].中华实用诊断与治疗杂志,2010,24(03):226-228.
26.单乐群,马保安,张勇,郑联合,李军,王育才,范清宇.浮膝损伤合并血管损伤的处理[J].中国现代手术学杂志,2010,14(01):5-8.
27.单乐群,马保安,张勇,郑联合,李军,王育才,范清宇.足踝部皮肤软组织缺损游离皮瓣修复[J].中华实用诊断与治疗杂志,2010,24(02):119-120+124.
28.单乐群,裘秀春,马保安,周勇,王育才,张殿忠,范清宇.中低温度热疗诱导骨肉瘤细胞株凋亡[J].第四军医大学学报,2007(16):1482-1484.
29.单乐群,周本根,裘秀春,许彦鸣,张正平,李伟,高杰,马保安,杨安钢,范清宇.人重组型caspase-6融合蛋白对骨肉瘤E10细胞的靶向促凋亡作用[J].实用医学杂志,2007(08):1107-1109.
30.单乐群. 加热对成骨肉瘤细胞系OS—9901和SOSP—M3的体外灭活作用及加热诱导骨肉瘤细胞系OS—9901的凋亡作用[D].中国人民解放军第四军医大学,2003.
31.单乐群,范清宇,张殿忠,马保安,周勇,王育才,胡运生.加热对骨肉瘤细胞系OS-9901和SOSP-M3的体外灭活作用[J].第四军医大学学报,2002(24):2275-2278.
32.单乐群,范清宇,张殿忠,赵廷宝,马保安,周勇,文艳华.骨移植替代材料的进展:活性煅烧骨颗粒复合骨水泥修复狗椎板缺损[J].现代康复,2001(20):55-56.
获 奖：
荣立个人三等功一次
西安英才计划领军创新人才
西安市红会医院中青年领军人才
专 利：
1. 骨科颈部压迫固定装置. 姜扩，单乐群，张吉涛.2021.04.20.实用新型专利.ZL202020992423.7
2. 骨科手术用定位打孔装置. 姜扩，单乐群，张吉涛. 2021.04.30.实用新型专利.ZL202021110582.6
3. 一种用于胸腰椎椎板及椎弓根峡部的内固定系统.单乐群，郝定均，糜宝国，姜扩.2020.12.17.实用新型专利.ZL202023059964.3
4. 一种医疗用腿部伸展康复锻炼器械.都金鹏,黄大耿,单乐群,屠敏艳,王建.2020.02.14.发明专利ZL201810559725.2.
5. 一种经后路重建脊柱稳定性所用钛笼的把持钳. 都金鹏，单乐群，郝定均，王文涛，樊勇，张嘉男，催竹青，薛徐凯，白露露.2020.08.01.实用新型专利201922268914.7.
6. 医用螺钉取出器. 姜扩，李佳，单乐群，张吉涛.2020.09.18.实用新型专利ZL201922051956.5. |
