科研项目: 1.国家自然科研基金项目: 乙酰左旋肉碱对大鼠急性脊髓损伤后线粒体氧化应激和自噬的调节及机制研究,33w,主持。 2.国家自然科研基金项目: 姜黄素对大鼠急性脊髓损伤保护作用的机制研究,10w,主持。 3.陕西省重点研项目陕西省科技厅项目一般项目:姜黄素激活SCFAs/GPRs/Treg通路促进脊髓损伤修复的实验研究,6w,主持。 4.陕西省科技厅项目社发公关项目:姜黄素调节JAK2/STAT3和PI3K/AKT/mTOR通路修复大鼠脊髓损伤的实验研究,7w,主持。 学术论文: 1.Bai X, Yang Y, Luo Y, Zhang D, Zhai T, Hu Q, Zhang N, Dai Q, Liang J, Bian H, Liu X. Design and synthesis of sulfonamide phenothiazine derivatives as novel ferroptosis inhibitors and their therapeutic effects in spinal cord injury. Bioorg Chem. 2024 May 19;148:107458. 2.Liang J, Ma T, Li Y, Sun R, Zhao S, Shen Y, Gao H, Jing Y, Bai X, He M, Wang Q, Xi H, Shi R, Yang Y. Association between sleep duration and serum neurofilament light chain levels among adults in the United States. Heliyon. 2024 May 4;10(10):e30699. 3.Bai X-Y, Liu X-L, Deng Z-Z, Wei D-M, Zhang D, Xi H-L, Wang Q-Y, He M-Z and Yang Y-L. Ferroptosis is a new therapeutic target for spinal cord injury. Front. Neurosci. 2023; 17:1136143. 4.Shen J, Gao F, Zhao L, Hao Q, Yang YL. MicroRNA-34c promotes neuronal recovery in rats with spinal cord injury through the C-X-C motif ligand 14/Janus kinase 2/signal transducer and activator of transcription-3 axis. Chin Med J (Engl). 2020 Sep 20;133(18):2177-2185. 5.Yu Su, Gangying Yu, Dongchen Li, Yao Lu, Cheng Ren, Yibo Xu, Yanling Yang, Kun Zhang, Teng Ma, Zhong Li. Identification of mitophagy-related biomarkers in human osteoporosis based on a machine learning model. Frontiers in Physiology 14. 6.Qiang RR, Xiang Y, Zhang L, Bai XY, Zhang D, Li YJ, Yang YL, Liu XL. Ferroptosis: A New Strategy for Targeting Alzheimer's Disease. Neurochem Int. 2024 May 22:105773. 7.Zhang L, Luo YL, Xiang Y, Bai XY, Qiang RR, Zhang X, Yang YL, Liu XL. Ferroptosis inhibitors: past, present and future. Front. Pharmacol., 23 May 2024. 8.Wang LY, Zhang L, Bai XY, Qiang RR, Zhang N, Hu QQ, Cheng JZ, Yang YL, Xiang Y. The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment. Neurochem Res. 2024 Jun 12. 9.Feng gao, Juan Shen, Lin Zhao, Qin Hao, Yanling Yang*. Curcumin alleviates lipopolysaccharide (LPS)-activated neuroinflammation via modulation of miR-199b-5p/IkB kinase b (IKKb)/nuclear factor kappa B (NF-kB) pathway in microglia, Med Sci Monit, 2019; 25: 9801-9810. 10.Zhe Ji, ZhiLan Zhou, Qin Hao, Lin Zhao, Chun Cui, ShuBing Huang, Yanling Yang*, Yan-Qin Shen. Activating transcription factor 6 contributes to functional recovery after spinal cord injury in adult zebrafish. J of Mol Neurosci, 2021, 71: 734–745. 11.Feng Gao, Jing Lei, Zhaowei Zhang, Yanling Yang, Haojun You. Curcumin alleviates LPS-induced inflflammation and oxidative stress in mouse microglial BV2 cells by targeting miR-137-3p/NeuroD1, Rsc Adv, 2019, 9, 38397-38406. 12.Shen J, Gao F, Zhao L, Hao Q, Yang YL. MicroRNA-34c promotes neuronal recovery in rats with spinal cord injury through the C-X-C motif ligand 14/Janus kinase 2/signal transducer and activator of transcription-3 axis. Chin Med J (Engl). 2020 Sep 20;133(18):2177-2185. |