科研项目: 1.国家自然基金面上项目:Intelectin基因异常高表达在支气管哮喘气道粘液过度分泌中的作用(编号:307709414); 2.国家自然基金青年项目:雷帕霉素靶蛋白/核糖体蛋白S6激酶1(mTOR/S6K1)信号通路在颞叶癫痫发生发展中的调控机制研究(编号81201004); 3.微小RNA155经Rheb/mTor通路在缺血性脑损伤中的作用及其机制研究(编号81501139); 4.Omentin调控SLIT3/ROBO4信号激活血管生成对缺血性脑损伤的保护作用研究(编号81660210)。 主持陕西省自然基金项目3项及西安市科技计划项目2项: 1.陕西省自然基金面上项目,Intelectin在病毒性脑炎炎症表达中作用及机制研究(2014JM4162); 2.陕西省自然基金面上项目:Intelectin在脑梗死血管再生和抗凋亡中的作用(2018JM7097); 3.西安市科技计划项目:Intelectin联合骨髓间充质细胞对脑梗死治疗的作用及机制研究(2019114613YX001SF039); 4.陕西省自然基金面上项目:Itln-1修饰的MSCs对脑梗死血管再生和抗凋亡作用,(2021JM562); 5.西安市科技计划项目:Intelectin联合骨髓间充质细胞调控Gas6/Axl通路激活血管再生对脑梗死神经保护作用,(2023YXYJ0036); 6.MiRNA-29a-3p通过PI3K/AKT/mTOR信号通路在神经脑保护中的作用机制研究 西安市中心医院院级基金 (2024-2025) 学术论文: 1.Gu N, Wang X, Di Z, et al. Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis. Aging (Albany NY). 2019; 11(22):10266–10283 2.Gu N, Wang J, Di Z, et al. The Effects of Intelectin-1 on Antioxidant and Angiogenesis in HUVECs Exposed to Oxygen Glucose Deprivation. Front Neurol. 2019; 10:383. 3.Gu N, Dong Y, Tian Y, et al. Anti-apoptotic and angiogenic effects of intelectin-1 in rat cerebral ischemia. Brain Res Bull. 2017; 130:27–35. 4.Gu N, Rao C, Tian Y, et al. Anti-inflammatory and antiapoptotic effects of mesenchymal stem cells transplantation in rat brain with cerebral ischemia.[J]. Journal of Stroke & Cerebrovascular Diseases the Official Journal of National Stroke Association, 2014, 23(10):2598. 5.Gu N, Tian Y, Di Z, et al. Shuanghuanglian injection downregulates nuclear factor-kappa B expression in mice with viral encephalitis[J]. Neural Regeneration Research, 2012, 7(33):2592-9. 6.Gu N, Kang G, Jin C, et al. Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation.[J]. American Journal of Physiology, 2010, 298(1):290-296. 7.顾乃兵,田晔,李安泰等. 复发性缺血性卒中患者抗心磷脂抗体水平与血糖、血脂的关系[J]. 实用临床医药杂志, 2015, 19(17):151-153. 8.郭 坤,朱 博,李 蓉,郗 静,王 宁,狄政莉,顾乃兵. 外泌体中miRNAs在缺血性脑卒中的研究进展. Advances in Clinical Medicine 临床医学进展, 2023, 13(4), 5848-5854. 9.Yue Ma,Zhiqin Liu,Lele Deng,Jingjing Du,Naibing Gu Zhengli Di,Yu Zhang et al. FGF21 attenuates neuroinflammation following subarachnoid hemorrhage through promoting mitophagy and inhibiting the cGAS-STING pathway. J Transl Med,2024 May 8;22(1):436. 10.Kun Guo, Bo Zhu, Rong Li, Jing Xi, Qi Wang, KongBo Chen, Yuan Shao, Jiaqi Liu, Weili Cao, Zhiqin Liu, Zhengli Di and Naibing Gu. Machine learning-basednomogram: integrating MRI radiomics and clinical indicators for prognostic assessment in acute ischemic stroke. Front. Neurol. 2024,15:1379031. doi: 10.3389/fneur.2024.1379031 11.Fan-Ya Sun, Jia Shen, Le Ding, Bo Zhu, Naibing Gu, Zhiqin Liu, Zhengli Di, Xiao-Tao Jia. Bilateral pontine brachium lesions in one autoantibodies directed against MOG positive patient.• Medicine (2024) 103:32. 获 奖: 2024年获得九三学社西安市九三英才奖1项 2021年获得陕西省科技进步三等奖(第二完成人):基于神经保护的缺血性脑卒中精准诊疗应用(2020-J-204211-3-R02) 2018年获得西安市自然科学论文二等奖; 专 利: 2020、2022年各获得实用专利一项; |