科研项目（在研）：
1. 国家自然科学基金面上项目（82071551）PBAE纳米颗粒介导促神经转录因子ASCL1和NGN2基因转导消融胶质瘢痕促脊髓再生的作用及分子机制2021.1.01-2024.12.31。57万 主持
2. 自治区重点研发项目（2022BEG02032）脑脊髓损伤及退变的靶向消融胶质瘢痕转化研究2022.1.01-2025.12.31 140万 主持
3. 西安市卫健委面上培育项目（2024ms12）ASCL1/NGN2基因转导调节Cend1/p53信号靶向诱导胶质瘢痕重编程为神经元促脊髓再生的研究2024.1.01-2025.12.31 含配套16万 主持
4. 西安市科技计划项目（24YXYJ0067）纳米颗粒负载促神经转录因子靶向消融消融胶质瘢痕治疗脊髓再生的研究2024.6.01-2026.05.31 含配套10万 主持
学术论文（近5年发表论文，*通讯作者）：
1)Jianbin Guo , Xiangwen Tang , Peng Deng , Hao Hui , Bo Chen , Jing An , Gaorong Zhang , Kuohao Shi , Jinchao Wang , Yuqing He , Dingjun Hao, Yang Hao* Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia/macrophage in OEC anti-infammatory activity for functional repair of spinal cord injury. Cell Communication and Signaling. 2024; 22:162
2)Yuqing He, Yizhen Jiang, Lianwei Dong, Chao Jiang, Lingling Zhang, Gaorong Zhang, Hao Yang*, Juan Liu. The aOECs facilitate the neuronal differentiation of neural stem cells in the inflammatory microenvironment through up-regulation of bioactive factors and activation of wnt3/β-catenin pathway. Mol Neurobiol. 2023; 60(2):789-806
3)Tang Xiangwen, Deng Peng, Jiang Yizhen, Zhang Lingling, He Yuqing, Yang Hao*. An overview of recent advances in the neuroprotective potentials of fisetin against diverse insults in neurological diseases and the underlying signaling pathways. Biomedicines. 2023;11(11):2878
4)Jiang Yizhen, Tang Xiangwen, Deng Peng, Jiang Chao, He Yuqing, Hao Dingjun, Yang Hao*. The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review. Mol Neurobiol. 2023; 60(11):6383-6394.
5)Jiang Chao, Chen Zhe, Wang Xiaohui, Zhang Yongyuan, Guo Xiyu, Fan Hao, Huang Dageng, He Yuqing, Tang Xiangwen, Ai Yixiang, Liu Youjun, Yang Hao*, Hao Dingjun. Curcumin-activated olfactory ensheathing cells improve functional recovery after spinal cord injury by modulating microglia polarization through APOE/TREM2/NF-κB signaling pathway. J Neuroimmune Pharmacol. 2023;18(3):476-494.
6)Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang,Xinyu Guo, Zhengwei Xu, Hao Yang* and Dingjun Hao. The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration. Front Endocrinol. 2022. 13:1081185
7)Zhe Chen, Hong Fan, ZiYi Chen, Chao Jiang, MingZhe Feng, XinYu Guo, Hao Yang* , DingJun Hao. OECs Prevented Neuronal Cells from Apoptosis Partially Through Exosome-derived BDNF. J Mol Neurosci. 2022 ;72(12):2497-2506
8)Yizhen Jiang, Jianbin Guo, Xiangwen Tang, Xiaohui Wang, Dingjun Hao, Hao Yang*. The immunological roles of olfactory ensheathing cells in the treatment of spinal cord injury. Front Immunol. 2022; 13: 881162.
9)Hong Fan, Zhe Chen, Haibin Tang, Le-Qun Shan, Zi-Yi Chen, Shi-Chang Liu, Yong-Yuan Zhang, Xin-Yu Guo, Hao Yang* Dingjun Hao*. Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling. Front Endocrinol. 2022 Sep 21;13:994307.
10)Chao Jiang, Xiaohui Wang, Yizhen Jiang, Zhe Chen, Yongyuan Zhang, Dingjun Hao*, Hao Yang*. The Anti-inflammation Property of Olfactory Ensheathing Cells in Neural Regeneration After Spinal Cord Injury. Mol Neurobiol. 2022;59(10):6447-6459.( IF: 5.6817)
11)Yongyuan Zhang, Xiaohui Wang, Chao Jiang, Zhe Chen, Ni Shuangyang, Hong Fan, Zhiyuan Wang, Fang Tian, Jing An, Hao Yang*, Dingjun Hao*. Rho Kinase Inhibitor Y27632 Improves Recovery After Spinal Cord Injury by Shifting Astrocyte Phenotype and Morphology via the ROCK/NF-κB/C3 Pathway. Neurochem Res. 2022 Dec;47(12):3733-3744..
12)Jing An, Bo Chen, Ding Tian, Yunshan Guo, Yuzhu Yan, Hao Yang*. Regulation of Neurogenesis and Neuronal Differentiation by Natural Compounds. Curr Stem Cell Res Ther 2022;17(8):756-771 (IF:3.7579)
13)Yonglei Cai, Junliu Liu, Bin Wang, Miao Sun, Hao Yang*. Microglia in the Neuroinflammatory pathogenesis of alzheimer's disease and related therapeutic targets. Front Immunol. 2022 Apr 26;13:856376
14)Xiaohui Wang, Chao Jiang, Yongyuan Zhang, Zhe Chen, Hong Fan, Yuyang Zhang, Zhiyuan Wang, Fang Tian, Jing Li, Hao Yang*, Dingjun Hao*. The promoting effects of activated olfactory ensheathing cells on angiogenesis after spinal cord injury through the PI3K/Akt pathway. Cell & Bioscience. 2022; 12(1):23.
15)Hong Fan, Zhe Chen, Hai-Bin Tang, Le-Qun Shan, Zi-Yi Chen, Xiao-Hui Wang, Da-Geng Huang, Shi-Chang Liu, Xun Chen, Hao Yang*, Dingjun Hao*. Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microglia. Bioeng Transl Med. 2022; 7: e10287.
16)Jianbin Guo, Guoqing Yang, Yuqing He, Huiming Xu, Hong Fan, Jing An, Lingling Zhang, Rui Zhang, Guihua Cao, Dingjun Hao*, Hao Yang*. Involvement of α7nAChR in the protective effects of genistein againstβ‑Amyloid‑Induced oxidative stress in neurons via a PI3K/Akt/Nrf2 pathway related mechanism. Cellular and Molecular Neurobiology. 2021 41(2):377-393.
17)Guoqing Yang, Yuqing He, Hao Yang* The involvement of bioactive factors in the self-renewal and stemness maintenance of spermatogonial stem cells. Molecular and Cellular Biochemistry.2021; 476(4):1813-1823.
18)Bo Chen, Jingjing Zhao, Rui Zhang, Lingling Zhang, Qian Zhang, Hao Yang*, Jing An*. Neuroprotective effects of natural compounds on neurotoxin-induced oxidative stress and cell apoptosis. Nutritional Neuroscience. 2022;25(5):1078-1099.
19)Bo Chen, Jing An, Yun-Shan Guo, Juan Tang, Jing-Jing Zhao, Rui Zhang, Hao Yang*. Tetramethylpyrazine induces the release of BDNF from BM-MSCs through activation of the PI3K/AKT/CREB pathway Cell Biol Int. 2021;45(12):2429-2442
20)Yuqing He, Li Guo, Juan Ding, Haowen Lv, Quanrui Ma, Chen Li, Yu Shao, Qiang Liu, Chun Zhang, Hao Yang*, Juan Liu. Down-regulation of N-methyl-D-aspartate receptor subunits 1 affects neurogenesis of hippocampal neural stem cells. Biocell. 2021; 45(2):417-426.
21)An Jing, Chen Bo, Zhao Jingjing, Zhang Rui, Hao Yang*. Neuroprotective effects of natural compounds on LPS-induced inflammatory responses in microglia. Am J Transl Res 2020;12(6):2353-2378.
22)Jianbin Guo, Guihua Cao, Guoqing Yang，Yumin Zhang, Yakang Wang, Wei Song, Yayong Xu, Tao Ma, Rui Liu, Qian Zhang, Dingjun Hao, Hao Yang*. Transplantation of activated olfactory ensheathing cells by curcumin strengthens regeneration and recovery of function after spinal cord injury in rats. Cytotherapy. 2020; 20(6):310-312.
23)Zhe Chen, Fan Hong, Zhiyuan Wang, Dingjun Hao, Hao Yang*.Spermatogonial stem cells are a promising and pluripotent cell source for regenerative medicine. Am J Transl Res 2020;12(11):7048-7059
24)Hao Yang*, Cuicui Liu, Hong Fan, Bo Chen, Dageng Huang, Lingling Zhang, Qian Zhang, Jing An, Jingjing Zhao, Yi Wang, Dingjun Hao. Sonic Hedgehog Effectively Improves Oct4-Mediated Reprogramming of Astrocytes into Neural Stem Cells. Mol Therapy. 2019; 27(8):1467-1482.
25)Hong Fan, Lequn Shan, Haibin Tang, Lequn Shan, Shichang Liu1, Dageng Huang, Xun Chen, Zhe Chen, Ming Yang, Xinhua Yin, Hao Yang*, Dingjun Hao. Quercetin Prevents Necroptosis of Oligodendrocytes by Inhibiting Macrophages/Microglia Polarization to M1 Phenotype after Spinal Cord Injury in Rats.2019, J Neuroinflamm. 2019 16:206
26)Hao Yang*, Dingjun Hao, Cheng Liu, Dageng Huang, Bo Chen, Hong Fan, Cuicui Liu, Lingling Zhang, Qian Zhang, Jing An, Jingjing Zhao. Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes. Stem Cell Research & Therapy. 2019; 10(1):195. 10.1186/s13287-019-1294-x.
27)Qian Zhang, LiXin Zhang, Jing An, Liang Yan, Cuicui Liu, Jingjing Zhao, Hao Yang*. Huangqin flavonoid extraction for spinal cord injury in a rat model. Neural Regen Res. 2018; 13(12): 2200-2208.
获 奖：
1.脊柱损伤修复关键技术的基础研究与临床应用, 陕西省人民政府, 科技进步省部一等奖2016
2.中国中青年脊髓损伤康复优秀人才奖, 中国残疾人康复协会中国脊髓损伤康复专业委员会2016,
专 利：
1. 一种重组多功能生长因子Pleioterophin融合蛋白及其制备方法，发明专利 （ZL 2013 10068275.4）
2.一种干细胞源外泌体的制备装置，实用专利（ZL 2023 2 1867991.4） |
