科研项目：
1.基于SCI动态病理变化的多靶向治疗促脊髓再生修复及相关机制研究，国家基金委（81830077），2019.01-2023.01，第4完成人，297万元；
2.激活态OECs协同SSCs源性神经元促脊髓损伤修复的作用及分子机制，国家基金委（81401843），2018.01-2021.12，第2完成人，55万元；
3.过度活化的骨形态发生蛋白及其受体信号传导通路在后纵韧带骨化中的病理机理研究，国家基金委（81401843），第1完成人，23万元；
4.MZF1 通过靶向 PKM2 信号抑制破骨细胞乳酸合成：骨质疏松病理发生新机制，国家基金委（82260181），2023.01-2026.12，第1完成人，33万元；
5.MZF1 调控破骨细胞糖代谢及分化进程的作用机理，陕西省科技厅-重点项目（2022JZ-43），2022.01-2024.12，第1完成人，20万元；
6.脊柱损伤修复关键技术的创新与应用，西安市卫健委-领军人才项目（XARC220101），
2022.01-2025.01，第一完成人，50万元；
7.面向高能量创伤的骨科机器人远程诊疗应用示范与评价，国家科学技术部，国家重点研发计划（2022YFC2407503），2022.11-2025.10，第一完成人，130万元；
8.老年骨质疏松性胸腰椎骨折ASOTLF分型系统的建立与推广及钛涂层椎体桥接系统的研发与应用，西安市科学技术局，医学研究重点项目（2024JH-YXZD-0055），2024.01-2026.01，第1完成人，30万元；
学术论文：
1.Yining Gong, Bin Zhu, Yurong Chen, Furong Li, Wanglin Duan, Sergio Martin-Saldana, Ruopei Yang, Xiangcheng Gao, Bo Zhang, Lei Luo, Zhengtao Xiao, Baoji Du,* Liang Yan,* and Yazhong Bu*. Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion. ACS nano, 2024. (IF=15.8, Q1)
2.Xiangcheng Gao, Lan Liu, Haiwei Hou, Weijuan Jia, Aoxue Zhang, Bo Zhang, Yazhong Bu, Yining Gong, Liang Yan*, Baoji Du. Construct a Magnetic Pt/Ru Alloy Peroxidase Mimic As a Reusable and Cost-Effective "Signal-Off" Sensing Platform for Sensitive and Wide-Linear-Range Assay. Analytical chemistry, 2024. (IF=7.4, Q1)
3.Tun Liu , Gang Wu , Wentao Wang , Huaguang Qi , Songchuan Zhao , Jitao Zhang , Ruiguo Wang , Tao Yuan , Li Xiao , Zhenguo Luo , Weizhou Yang , Fei Wang , Gang Wang , Liang Yan*. Utility of somatosensory- and motor-evoked potential change thresholds in surgical treatment for thoracic spinal stenosis based on different pathologies. The Spine Journal, 2023, 27:S1529-9430(24)00198-0. (IF=4.5, Q1)
4.Zhang, Bo; Gong, Yining; Liu, Lan; Hou, Haiwei; Gao, Xiangcheng; Bu, Yazhong; Du, Baoji; Yan, Liang*. Hydrogel-embedded platinum-ruthenium alloy peroxidase mimic as a visual sensor for “signal-on” alkaline phosphatase detection. ACS Applied Nano Materials, 2024. (IF=5.9, Q2)
5.Bo Zhang†, Zechao Qu†, Hua Hui, Baorong He, Yining Gong, Xiangcheng Gao, Dong Wang, Yong Zhang, Yiwei Zhao, Jingjun Zhang, Liang Yan*. Effects and Mechanisms of Isoorientin for the Treatment Osteoporosis Based on Network Pharmacology and Experimental Validation. Molecular Medicine, 2024,30:27. (IF=5.7, Q2)
6.Zechao Qu, Bo Zhang, Lingbo Kong, Yong Zhang, Yiwei Zhao, Yining Gong, Xiangcheng Gao, Mingzhe Feng, Jingjun Zhang, Liang Yan*. Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2/GPX4 signaling pathway. Journal of Leukocyte biology, 2024. (IF=5.5, Q2)
7.Jinpeng Du#, Xiangcheng Gao#, Dingjun Hao, Zhengxue Quan, Liang Yan*, Baorong He*. Retrospective analysis of 10 cases with esophageal fistula after anterior surgery for cervical spine fracture. Heliyon, 2023,23;9(11):e21244 (IF=4.0, Q2)
8.Yiwei Zhao*, Zechao Qu*, Songchuan Zhao, Yong Zhang, Yining Gong, Bo Zhang, Xiangcheng Gao, Dong Wang, Liang Yan*. The Potential of Natural Compounds Regulating Autophagy in the Treatment of Osteoporosis. Journal of inflammation research, 2023, 8:16:6003-6021. (IF=4.5, Q2)
9.Yong Zhang#, Zechao Qu#, Yiwei Zhao, Bo Zhang, Yining Gong, Xiaohui Wang, Xiangcheng Gao, Dong Wang and Liang Yan*. The Therapeutic Effect of Natural Compounds on Osteoporosis through Ferroptosis. Current Medicinal Chemistry, 2023. (IF=4.1, Q2)
10.Yining Gong, Dingjun Hao, Yong Zhang, Yongyong Tu, Baorong He, Liang Yan*. Molecular Subtype Classification of Postmenopausal Osteoporosis and Immune Infiltration Microenvironment Based on Bioinformatics Analysis of Osteoclast-Regulatory Genes. Biomedicines, 2023, 11, 2701.( IF=4.7, Q2)
11.Yang Yuan, Yongjie Zhang, Xiao Song, Xin Zhang, Chunjuan Li, Tao Yuan, Huaguang Qi, Liang Yan*. Value of multi‑channel somatosensory evoked potentials recording in patients undergoing scoliosis correction surgery. European Spine Journal, 2023.( IF=2.8, Q2)
12.Wangli Huang, Yining Gong and Liang Yan*. ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review. Biomolecules, 13(7):1050, 2023. (IF=5.5, Q2)
13.Mingzhe Feng, Lin Liu, Zechao Qu, Bo Zhang, Yanjun Wang, Liang Yan*, Lingbo Kong. CRISPR/Cas9 knockout of MTA1 enhanced RANKL-induced osteoclastogenesis in RAW264.7 cells partly via increasing ROS activities. Journal of Cellular and Molecular Medicine, 2023. (IF=5.295, Q2)
14.Xiangcheng Gao, Jinpeng Du, Yongyuan Zhang, Yining Gong, Bo Zhang, Zechao Qu, Dingjun Hao, Baorong He, Liang Yan*. Predictive Factors for Bone Cement Displacement following Percutaneous Vertebral Augmentation in Kümmell's Disease. Journal of Clinical Medicine, 11(24): 7479, 2022. (IF=4.964, Q2)
15.Zechao Qu, Bo Zhang, Lingbo Kong, Yining Gong, Mingzhe Feng, Xiangcheng Gao, Dong Wang and Liang Yan*. Receptor activator of nuclear factor-κB ligand-mediated osteoclastogenesis signaling pathway and related therapeutic natural compounds. Frontiers in Pharmacology, 13:1043975, 2022. (IF=5.988, Q1)
16.Yining Gong, Yazhong Bu, Yongliang Li, Dingjun Hao*, Baorong He, Lingbo Kong, Wangli Huang, Xiangcheng Gao, Bo Zhang, Zechao Qu, Dong Wang and Liang Yan*. Hydrogel-based delivery system applied in the local anti-osteoporotic bone defects. Frontiers in Bioengineering and Biotechnology, 11:1058300, 2022. (IF=6.064, Q2)
17.Biao Wang, Yi Zhan, Liang Yan* and Dingjun Hao. How zoledronic acid improves osteoporosis by acting on osteoclasts. Frontiers in Pharmacology, 13:961964, 2022. (IF=5.988, Q1)
18.Zechao Qu, Hao An, Mingzhe Feng, Wangli Huang, Dong Wang, Zhen Zhang, Liang Yan*. Urolithin B suppresses osteoclastogenesis via inhibiting RANKL-induced signalling pathways and attenuating ROS activities. Journal of Cellular and Molecular Medicine, 26(16):4428-4439, 2022. (IF=5.295, Q2)
19.Yanjun Wang, Lin Liu, Zechao Qu, Dong Wang, Wangli Huang, Lingbo Kong and Liang Yan *. Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway. Frontiers in Cell and Developmental Biology, 10:878433, 2022. (IF=6.684, Q1)
20.Wangli Huang, Lingbo Kong, Yang Cao, Liang Yan*. Identification and Quantification, Metabolism and Pharmacokinetics, Pharmacological Activities, and Botanical Preparations of Protopine: A Review. Molecules, 27(1): 215, 2022. (IF=4.927, Q2)
21.Lingbo Kong, Rui Ma, Yang Cao, Wanli Smith, Yuan Liu, Xiaobin Yang, Liang Yan*. Cell cytoskeleton and proliferation study for the RANKL-induced RAW264.7 differentiation. Journal of Cellular and Molecular Medicine, 25(10):4649-4657, 2021. (IF=5.295，Q2)
获 奖：
1.2023 年获陕西省科技进步二等奖；
2.2023 年获陕西青年科技奖；
3.2022 年被评为陕西省中青年科技创新领军人才；
4.2022 年被评为西安市英才计划-领军人才；
5.2022 年被评为西安市第五届“中国医师节”最美医师；
6.2021 年被评为陕西省五一劳动奖章；
7.2020 年被评为陕西五四青年奖章；
8.2019 年获中华医学会骨科创新与转化大赛全国一等奖；
9.2019 年获陕西省科技进步一等奖；
10.2019 年 被评为西安五四青年奖章；
11.2019 年被评为西安市人民健康卫士；
12.2018 年获国家科技进步二等奖；
13.2015 年获陕西省科技进步一等奖；
14.2015 年被评为西安市青年科技人才奖。
专 利：
1.一种脊柱侧弯矫正器，2017，中国，排名第1；
2.一种光源可控制细胞培养箱，2017，中国，排名第1；
3.细胞实验提取装置，2017，中国，排名第1；
4.一种手术床升降装置，2019，中国，排名第1；
5.一种 3D 打印人工颈椎间盘假体，2017，中国，排名第1；
6.椎间盘假体，2017，中国，排名第1。 |
