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许鹏
日期:2024年09月21日 16:03  发布人:  浏览量:
姓 名:许鹏

院 系:红会医院
职 称:主任医师
邮 箱:sousou369@163.com
研究领域:关节外科
个人简介
   一级主任医师,博士,西安市红会医院副院长,西安市红会医院关节病医院院长、西安交通大学博士研究生导师、国务院政府津贴专家。主要从事股骨头坏死及髋部相关疾病的临床诊疗及发病机制研究、膝髋人工关节置换术的临床应用。擅长股骨头坏死、骨性关节炎、先天性髋关节发育不良、类风湿性关节炎、强直性脊柱炎及大骨节病的手术、非手术治疗。对髋、膝人工关节置换技术有扎实的理论基础及丰富的操作经验,每年关节置换手术量千余例。
   近年来主要承担及负责中美及中德、中韩国际合作项目、国家自然科学基金项目、中国博士后科研基金项目及省部级项目十余项。发表论文210余篇,其中SCI收录110余篇,出版学术专著1部,副主编西安交通大学研究生教材1部,参编参译著作8部。研究成果获陕西省科学技术一等奖、二等奖、三等奖各1项,陕西高等学校科学技术一等奖2项、二等奖1项,西安市科学技术二等奖、三等奖各1项。
代表性成果
科研项目:
1.2003.12.1-今 高适配定制式人工膝关节激光增材制造应用示范,75万,参与人
2.2023.11.01-2026.06.30导航/手术机器人辅助人工膝关节置换术及术后智能康复体系的建立,100万,项目负责人
3.2021.01.01-2024.12.31  SFMBT2调控OA软骨细胞染色质重塑的研究 国家自然科学基金(82072432),55万,项目负责人
4.2020.05.01-2023.10.31 省委组织部领军人才项目,省委组织部,80万,项目负责人
5.2020.01.01-2022.12.21 面向骨科患者诊疗康复的可穿戴下肢外骨骼机器人关键技术研究,陕西省科技厅(2020GXLH-Y-007),50万,项目负责人
6.2018.01.01-2021.12.31 软骨中一个新circRNA的功能及在骨关节炎中的作用研究,国家自然科学基金面上项目(81772410),55万,项目负责人
7.2013.01.01-2016.12.31自吞噬在甲氨蝶呤诱导类风湿性关节炎滑膜成纤维细胞凋亡中的抗凋亡作用研究,国家自然科学基金面上项目(81271948),70万,项目负责人
8.2012.01.01-2012.12.31自吞噬在骨性关节炎中抗软骨细胞凋亡机制的研究,国家自然科学基金面上项目(81171742),14万,项目负责人
9.2011.01.01-2013.12.31 多孔钽孔壁的仿骨基质结构设计与关键技术研究,国家自然科学基金面上项目(51071120),38万,第一参加人,负责医学部分
10.2008-2010 重组GDF-5基因转染BMSCS修复关节软骨缺损的实验研究,省科技厅自然基金(SJ08-ZT12-6),2万,项目负责人
11.2008-2010膜性负压仪的研制及诱导骨组织再生的研究,中国博士后科学基金(2007 0421123),3万,项目负责人

学术论文:
1.Wang M, Li T, Tian J, Zhang L, Wang Y, Li S, Lei B, Xu P. Engineering Single-Component Antibacterial Anti-inflammatory Polyitaconate-Based Hydrogel for Promoting Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing and Skin Regeneration. ACS Nano. 2024 Jan 9  IF 17.8
2.Luo P , Wang H , Xu P .Unveiling The Multifunction of Beaded Stream-Like Co_9Se_8 Catalysts for Water Splitting, Reactive Oxygen Species Scavenging, and Hydrogen Anti-Inflammation[J].Advanced energy materials, 2024, 14(9):2302532.1-2302532.14. IF 27.8
3.Wang M, Xu P, Lei B. Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering. Bioact Mater. 2022 ;19:511-537.  IF 16.874
4.Wang M, Deng Z, Guo Y, Xu P. Designing functional hyaluronic acid-based hydrogels for cartilage tissue engineering. Mater Today Bio. 2022 ;17:100495. IF 10.761
5.Liu W, Chen M, Luo M, Li T, Hu C, Xie C, Li S, Leng T, Tian J, Xu P, and Lei B. Bioactive glass ions hydrogels with antiinflammation antioxidant capacity for treating inflammation-related diseases. Mater Design. 2023; 227, 111669. IF 9.417
6.Aihaiti Y, Tuerhong X, Zheng H, Cai Y, Yang M, Xu P. Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway. Clin Immunol. 2022 ;237:108964. IF 10.190
7.Yang M, Zheng H, Xu K, Yuan Q, Aihaiti Y, Cai Y, Xu P. A novel signature to guide osteosarcoma prognosis and immune microenvironment: Cuproptosis-related lncRNA. Front Immunol. 2022 ;13:919231.  IF 8.786
8.Feng R, Lu M, Liu L, Xu K, Xu P. Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis. Front Immunol. 2022;13:814303. IF 8.786
9.Kai-Xin L, Cheng C, Rui L, Zheng-Wei S, Wen-Wen T, Xu P. Roles of lncRNA MAGI2-AS3 in human cancers. Biomed Pharmacother. 2021;141:111812. IF 7.419

10.Yang M, Wan X, Zheng H, Xu K, Xie J, Yu H, Wang J, Xu P. No Evidence of a Genetic Causal Relationship between Ankylosing Spondylitis and Gut Microbiota: A Two-Sample Mendelian Randomization Study. Nutrients. 2023;15(4):1057. IF 6.706
11.Yu H, Wan X, Yang M, Xie J, Xu K, Wang J, Wang G, Xu P. A large-scale causal analysis of gut microbiota and delirium: A Mendelian randomization study. J Affect Disord. 2023;329:64-71. IF 6.533
12.Liu L, Luo P, Yang M, Wang J, Hou W,Xu P. The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review. Front Mol Biosci. 2022;9:1001212.  IF 6.113
13.Liu W, Feng M, Xu P. From regeneration to osteoarthritis in the knee joint: The role shift of cartilage-derived progenitor cells. Front Cell Dev Biol. 2022;10:1010818.  IF 6.081
14.Lin L, Luo P, Yang M, Wang J, Hou W, Xu P. Causal relationship between osteoporosis and osteoarthritis: A two-sample Mendelian randomized study. Front Endocrinol (Lausanne). 2022;13:1011246. IF 6.055
15.Wang M, Guo Y, Deng Z, Xu P. Engineering elastic bioactive composite hydrogels for promoting osteogenic differentiation of embryonic mesenchymal stem cells. Front Bioeng Biotechnol. 2022;10:1022153.  IF 6.064
16.Lu C, Qi H, Xu H, Hao Y, Yang Z, Yu W, Xu P. Global research trends of steroid-induced osteonecrosis of the femoral head: A 30-year bibliometric analysis. Front Endocrinol (Lausanne). 2022;13:1027603.  IF 6.055
17.Aihaiti Y, Song Cai Y, Tuerhong X, Ni Yang Y, Ma Y, Shi Zheng H, Xu K, Xu P. Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation. Front Pharmacol. 2021;12:672054.  IF 5.988
18.Yang M, Luo P, Zhang F, Xu K, Feng R, Xu P. Large-scale correlation analysis of deep venous thrombosis and gut microbiota. Front Cardiovasc Med. 2022;9:1025918. IF 5.846

19.Yang Y, Wang T, Guo H, Sun Y, Cao J, Xu P, Cai Y. Development and Validation of a Nomogram for Predicting Postoperative Delirium in Patients With Elderly Hip Fracture Based on Data Collected on Admission. Front Aging Neurosci. 2022;14:914002.  IF 5.702
20.Feng R, Lu M, Yin C, Xu K, Liu L, Xu P. Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles. Arthritis Res Ther. 2023;25(1):19.  IF 5.606
21.Wang M, Deng Z, Guo Y, Xu P. Engineering functional natural polymer-based nanocomposite hydrogels for wound healing. Nanoscale Adv. 2022;5(1):27-45.  IF 5.598
22.He D, Pan C, Zhao Y, Wei W, Qin X, Cai Q, Shi S, Chu X, Zhang N, Jia Y, Wen Y, Cheng B, Liu H, Feng R, Zhang F, Xu P. Exome-wide screening identifies novel rare risk variants for bone mineral density. Osteoporos Int. 2023: 36849660. IF 5.071
23.Hou W, Xu L, Wang J, Wang B, Liu L, Xu K, Cai Y, Guo H, Xu P. Fabellar prevalence, degeneration and association with knee osteoarthritis in the Chinese population. Sci Rep. 2019;9(1):13046. IF 4.996
24.Luo P, Xu J, Cheng S, Xu K, Jing W, Zhang F, Xu P. Large-scale genetic correlation scanning and causal association between deep vein thrombosis and human blood metabolites. Sci Rep. 2022;12(1):7888. IF 4.996
25.Wan X, Xie J, Yang M, Yu H, Hou W, Xu K, Wang J, Xu P. Does Having Rheumatoid Arthritis Increase the Dose of Depression Medications? A Mendelian Randomization Study. J Clin Med. 2023;12(4):1405. IF 4.964
26.Yang M, Xu J, Zhang F, Luo P, Xu K, Feng R,Xu P. Large-Scale Genetic Correlation Analysis between Spondyloarthritis and Human Blood Metabolites. J Clin Med. 2023;12(3):1201. IF 4.964
27.Luo P, Wang M, Liu W, Liu L, Xu P. Activity-Based Fluorescent Probes Based on Hemicyanine for Biomedical Sensing. Molecules. 2022 ;27(22):7750. IF 4.927
28.Luo P, Cheng S, Zhang F, Feng R, Xu K, Jing W, Xu P. A large-scale genetic correlation scan between rheumatoid arthritis and human plasma protein. Bone Joint Res. 2022;11(2):134-142. IF 4.401
29.Xie J, Yang M, Yu H, Xu K, Wan X, Wang J, Wang G, Xu P. No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study. Genes (Basel). 2022;13(12):2270.  IF 4.141

30.Lu C, Song J, Li H, Yu W, Hao Y, Xu K,Xu P. Predicting Venous Thrombosis in Osteoarthritis Using a Machine Learning Algorithm: A Population-Based Cohort Study. J Pers Med. 2022;12(1):114. IF 3.508
31.Luo P, Liu L, Hou W, Xu K, Xu P. Gene Set Enrichment Analysis Detected Immune Cell-Related Pathways Associated with Primary Sclerosing Cholangitis. Biomed Res Int. 2022;2022:2371347. IF 3.246
32.Sun J, Min Z, Zhao W, Hussain S, Zhao Y, Guo D, Zhang F, Guo Y, Sun M, Huang H, Han Y, Zhong N, Xu P, Lu S. T-2 Toxin Induces Epiphyseal Plate Lesions via Decreased SECISBP2-Mediated Selenoprotein Expression in DA Rats, Exacerbated by Selenium Deficiency. Cartilage. 2021;12(1):121-131. IF 3.117
33.Cheng B, Jia Y, Wen Y, Hou W, Xu K, Liang C, Cheng S, Liu L, Chu X, Ye J, Yao Y, Zhang F, Xu P. Integrative Analysis of MicroRNA and mRNA Sequencing Data Identifies Novel Candidate Genes and Pathways for Developmental Dysplasia of Hip. Cartilage. 2021;13(2_suppl):1618S-1626S.  IF 3.117
34.Lu C, Peng K, Guo H, Ren X, Hu S, Cai Y, Han Y, Ma L, Xu P. miR-18a-5p promotes cell invasion and migration of osteosarcoma by directly targeting IRF2. Oncol Lett. 2018;16(3):3150-3156. IF 3.111
35.Feng R, Lu M, Yang Y, Luo P, Liu L, Xu K, Xu P. Genome- and transcriptome- wide association studies show that pulmonary embolism is associated with bone- forming proteins. Expert Rev Hematol. 2022;15(10):951-958. IF 2.819
36. Luo P, Xu J, Xu K, Jing W, Liu L, Xu P. Exploring the genetic relationship between deep vein thrombosis and plasma protein: a new research idea. Expert Rev Hematol. 2022 ;15(9):867-873.  IF 2.819
37.Liang Y, Xu K, Liu W, Liu X, Yuan P, Xu P, Li H. Monomeric C-reactive protein level is associated with osteoarthritis. Exp Ther Med. 2022;23(4):277. IF 2.751
38.Zhang BF, Zhuang Y, Liu L, Xu K, Wang H, Wang B, Wen HQ, Xu P. Current indications for acute total hip arthroplasty in older patients with acetabular fracture: Evidence in 601 patients from 2002 to 2021. Front Surg. 2023;9:1063469.  IF 2.568
39.Yuan Q, Wang X, Cai Y, Yang M, Zheng H, Zhao X, Ma H, Xu P. Total hip arthroplasty for posttraumatic osteoarthritis secondary to acetabular fracture: An evidence based on 1,284 patients from 1970 to 2018. Front Surg. 2022;9:953976. IF 2.568
40.Yang M, Zheng H, Su Y, Xu K, Yuan Q, Aihaiti Y, Cai Y,Xu P. Bioinformatics Analysis Identified the Hub Genes, mRNA-miRNA-lncRNA Axis, and Signaling Pathways Involved in Rheumatoid Arthritis Pathogenesis. Int J Gen Med. 2022;15:3879-3893. IF 2.466

获 奖:
1.2022年,陕西省医学会,陕西省科学技术奖:关节炎软骨破坏机制新发现及防治体系的建立与推广,二等奖
2.2012年,陕西省人民政府,陕西省科学技术奖:大骨节病分子发病机制及生物填充疗法的研究,一等奖
3.2013年,陕西省教育厅,陕西省高等学校科学技术奖:大骨节病分子发病机制及生物填充疗法的研究,一等奖
4.2005年,陕西省人民政府,陕西省科学技术奖:地方性氟骨症软骨损伤的发病机制及补硼防治效果的研究,三等奖
5.2004年,陕西省教育厅,陕西省高等学校科学技术奖:地方性氟骨症及中药“硼复方”防治对软骨损伤及胶原表型表达影响机制的实验研究,一等奖
6.2007年,陕西省教育厅省,陕西省高等学校科学技术奖:《椎间盘学研究》,二等奖
7.2005年,西安市人民政府,西安市科学技术奖:骨中提取多肽类物质谷康泰灵治疗骨质疏松实验及基础研究,二等奖
8.2011年,西安市人民政府,西安市科学技术奖:磨损微粒、界膜、细胞因子与人工关节松动的相关性研究,三等奖

专 利:                            
1.一种髋臼骨折术后用定位结构,ZL 2022 2 1503242.9,许珂,侯卫坤,鲁超,许鹏,实用新型专利,2023.1.17
2.缓解颈肩腰腿痛的间充质干细胞外泌体微针贴片及其制备方法,CN 115177851 A,袁启令,王馨怡,许鹏,蔡永松,袁小会,杨明义,赵晓明,郑海石,武美娜,发明专利,2022.10.14
3.一种套索驱动髋关节串联弹性助力外骨骼机器人,CN112548993A,朱爱斌,王英旭,屠尧,朱鹏程,许鹏,侯卫坤,姚丹丹,段琛,发明专利,2021.03.26
4.一种膝关节外骨骼康复训练轮椅,CN113397851A,朱爱斌,张晶,宋纪元,许鹏,候卫坤,姚丹丹,段琛,发明专利,2022.10.25
5.一种变刚度绳驱动的膝关节康复系统,发明专利,202210450954.7(已受理)
6.一种串联弹性驱动可变阻尼的膝关节康复系统,发明专利,202210452236.3(已受理)
7.一种具有可控力学性质的温敏性抗炎聚衣康酸酯水凝胶及其制备方法,许鹏,王敏,雷波,2023100797751,发明专利,2023.01.23(已受理)
8.一种用于缓解骨关节炎的可注射抗炎水凝胶及其制备方法和应用,许鹏,王敏,雷波,2023100485868,发明专利,2023.01.31(已受理)


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